Here's what rhymes with vacuole.
whole role soul coal goal hole pole roll sole bowl fol mole poll toll knoll shoal dole foal bole boll thole vole kohl tole dolour stole parole scroll droll cajole troll prole skoal stroll enroll systole casserole extol unroll condole oriole maypole extoll rissole control patrol glycerol petiole bedroll camisole cubbyhole innersole quadrupole buttonhole beanpole arteriole decontrol pigeonhole profiterole