Here's what rhymes with upregulate.
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laid rage rape raid made trade page paid played shape afraid grade wage shade tape blade cage gauge maid prayed weighed bade fade grape sage arrayed babe cape gage arcade braid frayed grenade jade wade stage delayed stayed brigade blockade crusade forbade obeyed parade surveyed unpaid decayed evade repaid scrape spade sprayed swayed upgrade overlaid pervade sh staid strayed decade escape engage betrayed conveyed persuade portrayed invade cascade degrade retrograde barricade lemonade outweighed renegade displayed dismayed dissuade homemade promenade stockade disobeyed masquerade videotape laced raced raped raked based placed faced shaped taste waste faint paint traced haste saint waist baked chased paste braced chaste draped erased paced taint graced taped replaced quaint spaced acquaint scraped debased effaced staked complaint escaped embraced restraint encased constraint displaced disgraced distaste misplaced vouchsafed