Here's what rhymes with phosphodiester.

Consider these alternatives

hydroxyl / will polynucleotide / side deamination / information cleave / leave disulfide / sulfide hydrolyzing / rising thioether / whether imine / mean decarboxylation / relation cysteine / line hydrazone / shown crosslinking / thinking aliphatic / dramatic hydroxylation / relation phosphonate / late catalyse / size transesterification / education