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Here's what rhymes with mediastinum.

momediastinum midmediastinum pneumomediastinum hemomediastinum hydromediastinum

Consider these alternatives

gyri / highly submandibular / mandibular glenoid / avoid interstitium / meridian retroperitoneal / feel ethmoidal / colloidal tympanic / organic hemorrhoidal / colloidal submucosal / social haemolymph / since

Words that almost rhyme with mediastinum

heliotropum
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